منابع مشابه
Neuroprotection by estradiol.
This review highlights recent evidence from clinical and basic science studies supporting a role for estrogen in neuroprotection. Accumulated clinical evidence suggests that estrogen exposure decreases the risk and delays the onset and progression of Alzheimer's disease and schizophrenia, and may also enhance recovery from traumatic neurological injury such as stroke. Recent basic science studi...
متن کاملDifferential mechanisms of neuroprotection by 17 beta-estradiol in apoptotic versus necrotic neurodegeneration.
The major goal of this study was to compare mechanisms of the neuroprotective potential of 17 beta-estradiol in two models for oxidative stress-independent apoptotic neuronal cell death with that in necrotic neuronal cell death in primary neuronal cultures derived from rat hippocampus, septum, or cortex. Neuronal apoptosis was induced either by staurosporine or ethylcholine aziridinium (AF64A),...
متن کاملSex-specific role of thioredoxin in neuroprotection against iron-induced brain injury conferred by estradiol.
BACKGROUND AND PURPOSE Accumulation of iron after intracerebral hemorrhage causes free radical formation and oxidative damage resulting in liquefaction. The aim of this study was the investigation of molecular mechanisms underlying estrogen-mediated neuroprotective effect against iron-induced brain injury in vivo. METHODS Age-matched male and female Sprague-Dawley rats were stereotaxically in...
متن کاملNeuroprotection by dopamine agonists.
Research on Parkinson's disease has led to new hypotheses concerning the mechanisms of neurodegeneration and to the development of neuroprotective agents. Recent findings of impaired mitochondrial function, altered iron metabolism and increased lipid peroxidation in the substantia nigra of parkinsonian patients emphasize the significance of oxidative stress and free radical formation in the pat...
متن کاملNeuroprotection by recombinant thrombomodulin.
We examined whether recombinant human soluble thrombomodulin (rhs-TM) reduces compression trauma-induced spinal cord injury through protein C activation in rats. Administration of rhs-TM, either before or after the induction of spinal cord injury (SCI), markedly reduced the resulting motor disturbances. However, neither rhs-TM pretreated with an anti-rhs-TM monoclonal antibody (MAb) F2H5, which...
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ژورنال
عنوان ژورنال: Progress in Neurobiology
سال: 2001
ISSN: 0301-0082
DOI: 10.1016/s0301-0082(00)00025-3